Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946783 | 0.81 | OPRM1 (0.47) | OPRD1CA12ALDH1A1CA2LMNA | |
| SCHEMBL1193696 | 0.80 | OPRM1 (0.52) | OPRD1ALOX5LMNAOPRM1OPRK1 | |
| SCHEMBL9258923 | 0.80 | CYP3A4 (0.38) | OPRD1ALOX5CA12ALDH1A1CA2 | |
| SCHEMBL9429709 | 0.80 | ALOX5 (0.37) | OPRD1ALOX5OPRM1OPRK1HTR1D | |
| SCHEMBL9138011 | 0.80 | OPRD1 (0.63) | OPRD1ALOX5OPRM1OPRK1 | |
| SCHEMBL932071 | 0.80 | CHRNA1 (0.42) | OPRD1ALOX5ALDH1A1LMNAOPRM1 | |
| SCHEMBL1598578 | 0.80 | ALOX5 (0.37) | OPRD1ALOX5OPRM1OPRK1HTR1D | |
| SCHEMBL1255944 | 0.78 | OPRL1 (0.52) | OPRD1ALDH1A1LMNAOPRM1OPRK1 | |
| SCHEMBL6681808 | 0.78 | DRD2 (0.50) | OPRD1CA12ALDH1A1CA2LMNA | |
| SCHEMBL9136443 | 0.77 | ALOX5 (0.45) | OPRD1ALOX5OPRM1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087250-A2 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| CN-1031266-C | Process for preparation of heterocycle ether derivatives | ZENECA LTD (GB) | 1996-03-13 | — | — | CN | disclosed |
| EP-0385662-B1 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-13 | — | — | EP | disclosed |
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |