SCHEMBL9260600

SCHEMBL9260600

CN1CC2CCCCN2C1=O

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.40
MEN1 O00255 1/20 0.38
MAPT P10636 1/20 0.38
BRCA1 P38398 1/20 0.38
KMT2A Q03164 1/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MAPK1 P28482 1/20 0.38
ADORA3 P0DMS8 1/20 0.37
ADORA2A P29274 1/20 0.37
NOS3 P29474 1/20 0.36
NOS1 P29475 1/20 0.36
ALDH1A1 P00352 1/20 0.35
GSK3A P49840 1/20 0.35
GSK3B P49841 1/20 0.35
ADAM17 P78536 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16609886 0.94 NOS1 (0.42) GRM5MEN1KMT2AMAPK1NOS3
SCHEMBL16609902 0.94 NOS1 (0.42) GRM5MEN1KMT2AMAPK1NOS3
SCHEMBL761295 0.94 NOS1 (0.42) GRM5MEN1KMT2AMAPK1NOS3
SCHEMBL13208002 0.82 ADORA2A (0.42) ADORA3ADORA2ANOS3NOS1GSK3A
SCHEMBL23714592 0.77 MAPK1 (0.43) MAPK1ADORA2ANOS3NOS1
SCHEMBL13455158 0.77 NPY5R (0.43) MAPK1ADORA2ANOS3NOS1
SCHEMBL18390617 0.75 HTR2A (0.42)
SCHEMBL14826661 0.75 LMNA (0.36) MEN1MAPTBRCA1KMT2AATM
SCHEMBL15919806 0.75 LMNA (0.36) MEN1MAPTBRCA1KMT2AATM
SCHEMBL24736661 0.75 MAPT (0.36) GRM5MEN1MAPTBRCA1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240058316-A1 PRODRUG OF A PHENOLIC TRPV1 AGONIST FOR THE TREATMENT OF PAIN Concentric Analgesics, Inc. 2024-02-22 US disclosed
US-20240051921-A1 CRYSTALLINE FORM OF A PHENOLIC TRPV1 AGONIST PRODRUG Concentric Analgesics, Inc. 2024-02-15 US disclosed
US-20240050421-A1 PHARMACEUTICAL FORMULATIONS OF A PHENOLIC TRPV1 AGONIST PRODRUG Concentric Analgesics, Inc. 2024-02-15 US disclosed
WO-2023192375-A1 HSD17B13 INHIBITORS AND USES THEREOF FL2022-001, INC. (US) 2023-10-05 WO disclosed
WO-2023274390-A1 BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF 杭州和正医药有限公司 2023-01-05 WO disclosed
US-20220387395-A1 UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION NURIX THERAPEUTICS, INC. 2022-12-08 US disclosed
US-11464767-B2 Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia Concentric Analgesics, Inc. (US) 2022-10-11 US disclosed
WO-2022132646-A1 CRYSTALLINE FORM OF A PHENOLIC TRPV1 AGONIST PRODRUG Concentric Analgesics, Inc. (US) 2022-06-23 WO disclosed
WO-2022132650-A1 PRODRUG OF A PHENOLIC TRPV1 AGONIST FOR THE TREATMENT OF PAIN Concentric Analgesics, Inc. (US) 2022-06-23 WO disclosed
WO-2022132649-A1 PHARMACEUTICAL FORMULATIONS OF A PHENOLIC TRPV1 AGONIST PRODRUG Concentric Analgesics, Inc. (US) 2022-06-23 WO disclosed
US-20210008050-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA Concentric Analgesics, Inc. 2021-01-14 US disclosed
US-20210008050-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA Concentric Analgesics, Inc. 2021-01-14 US disclosed
US-10821105-B2 Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia Concentric Analgesics, Inc. (US) 2020-11-03 US disclosed
US-10821105-B2 Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia Concentric Analgesics, Inc. (US) 2020-11-03 US disclosed
US-20190216787-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA Concentric Analgesics, Inc. 2019-07-18 US disclosed
US-20190216787-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA Concentric Analgesics, Inc. 2019-07-18 US disclosed
EP-3463576-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA Concentric Analgesics, Inc. (US) 2019-04-10 EP disclosed
WO-2017205534-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA Concentric Analgesics, Inc. (US) 2017-11-30 WO disclosed
WO-2017205534-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA Concentric Analgesics, Inc. (US) 2017-11-30 WO disclosed
US-20120135997-A1 PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND SHIONOGI & CO., LTD. (JP) 2012-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240051921-A1 CRYSTALLINE FORM OF A PHENOLIC TRPV1 AGONIST PRODRUG TRPV1, TRPV4, TRPV3 GRM5 328/4885MEN1 3988/4885MAPT 655/4885
US-20120135997-A1 PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND BACE1, STS, APP GRM5 2955/4885MEN1 4518/4885MAPT 53/4885
US-20240050421-A1 PHARMACEUTICAL FORMULATIONS OF A PHENOLIC TRPV1 AGONIST PRODRUG TRPV1, TRPV3, TRPV2 GRM5 1186/4885MEN1 4630/4885MAPT 1384/4885
US-20210008050-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA TRPV1, TRPV4, TRPV2 GRM5 766/4885MEN1 4787/4885MAPT 2411/4885
US-10821105-B2 Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia TRPV1, TRPV4, TRPV2 GRM5 766/4885MEN1 4787/4885MAPT 2411/4885
US-11464767-B2 Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia TRPV1, TRPV4, TRPV2 GRM5 766/4885MEN1 4787/4885MAPT 2411/4885
US-20220387395-A1 UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION CBLB, CBL, CBLC GRM5 4476/4885MEN1 4354/4885MAPT 1811/4885
US-20190216787-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA TRPV1, TRPV4, TRPV2 GRM5 766/4885MEN1 4787/4885MAPT 2411/4885
US-20240058316-A1 PRODRUG OF A PHENOLIC TRPV1 AGONIST FOR THE TREATMENT OF PAIN TRPV1, OPRL1, TRPV2 GRM5 810/4885MEN1 4870/4885MAPT 2211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.