Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18569422 | 0.92 | KDM4E (0.72) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL9845445 | 0.92 | MEN1 (0.51) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL11436717 | 0.90 | MEN1 (0.52) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL9346956 | 0.86 | ALDH1A1 (0.47) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL926471 | 0.77 | SLC6A4 (0.51) | OPRM1SIGMAR1OPRL1OPRD1SLC22A1 | |
| SCHEMBL6003176 | 0.77 | MEN1 (0.47) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL5992122 | 0.76 | MITF (0.74) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL7905910 | 0.76 | MITF (0.74) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL2094921 | 0.76 | MEN1 (0.52) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL8913127 | 0.76 | OPRM1 (0.61) | KDM4EMEN1NPC1MITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5227492-A | Anticholesterol agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1993-07-13 | — | — | US | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |
| EP-0325397-A1 | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1989-07-26 | — | — | EP | disclosed |