Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | RHOA | P61586 | 2/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927794 | 0.88 | TRPM8 (0.60) | TRPM8IMPDH2AAK1WNT1GSK3B | |
| SCHEMBL2628762 | 0.78 | TRPM8 (0.62) | TRPM8TRPV1 | |
| SCHEMBL15133466 | 0.78 | TRPM8 (0.62) | TRPM8TRPV1 | |
| SCHEMBL2628779 | 0.77 | TRPM8 (0.58) | TRPM8TRPV1 | |
| SCHEMBL299356 | 0.77 | TRPM8 (0.58) | TRPM8TRPV1 | |
| SCHEMBL2628752 | 0.77 | TRPM8 (0.61) | TRPM8TRPV1 | |
| SCHEMBL6344545 | 0.77 | TRPM8 (0.61) | TRPM8 | |
| SCHEMBL10072944 | 0.77 | TRPM8 (0.61) | TRPM8TRPV1 | |
| SCHEMBL4817890 | 0.76 | TRPM8 (0.73) | TRPM8 | |
| SCHEMBL10073491 | 0.76 | TRPM8 (0.73) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868004-B2 | Menthane carboxamide derivatives having cooling properties | GIVAUDAN S.A. (CH) | 2011-01-11 | — | — | US | disclosed |
| EP-1853565-B1 | MENTHANE CARBOXAMIDE DERIVATIVES HAVING COOLING PROPERTIES | GIVAUDAN SA (CH) | 2010-09-22 | — | — | EP | disclosed |
| US-20080305051-A1 | Menthane Carboxamide Derivatives Having Cooling Properties | GIVAUDAN S.A. (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1853565-A1 | MENTHANE CARBOXAMIDE DERIVATIVES HAVING COOLING PROPERTIES | Givaudan SA (CH) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092074-A1 | MENTHANE CARBOXAMIDE DERIVATIVES HAVING COOLING PROPERTIES | GIVAUDAN SA (CH) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080305051-A1 | Menthane Carboxamide Derivatives Having Cooling Properties | MDH2, ME2, H1-0 | TRPM8 72/4885BRAF 2828/4885CREBBP 3214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.