Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265583 | 0.84 | ENPP2 (0.61) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL29796263 | 0.83 | HDAC3 (0.64) | PPARAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28467935 | 0.83 | HDAC3 (0.64) | PPARAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL11901010 | 0.81 | LMNA (0.69) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL11330626 | 0.80 | LMNA (0.58) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9850285 | 0.79 | LMNA (0.59) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9187158 | 0.79 | LMNA (0.59) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9644602 | 0.79 | NPC1 (0.61) | PPARAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL21998673 | 0.78 | ALDH1A1 (0.67) | LMNANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21998663 | 0.78 | ALDH1A1 (0.67) | LMNANPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5464865-A | Enzyme inhibitors as antiinflammatory agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |