Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068980 | 0.85 | POLB (0.61) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL14580288 | 0.81 | ALDH1A1 (0.62) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL6846422 | 0.81 | MAPT (0.62) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL9157991 | 0.81 | POLB (0.57) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL9158000 | 0.81 | POLB (0.57) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL628621 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL19425986 | 0.81 | ALDH1A1 (0.85) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL9886 | 0.81 | ALDH1A1 (0.85) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL11659850 | 0.79 | ALDH1A1 (0.81) | ALDH1A1MAPTMEN1KMT2ARXFP1 | |
| Hydrochloric Acid SCHEMBL9145715 | 0.79 | ALDH1A1 (0.81) | ALDH1A1MAPTMEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020016903-A1 | AN IMPROVED AND COMMERCIALLY VIABLE PROCESS FOR PREPARATION OF PYRROLE DERIVATIVES WITH IMPROVED IMPURITY PROFILE & MINIMISATION OF UNIT OPERATIONS. | ARCH PHARMALABS LIMITED (IN) | 2020-01-23 | — | — | WO | disclosed |
| EP-2279167-B1 | NOVEL PROCESS FOR THE PREPARATION OF 4-FLUORO-ALPHA-Ý2-METHYL -1-OXOPROPYL¨-GAMMA-OXO-N-ß-DIPHENYLBENZENEBUTANAMIDE AND PRODUCTS THEREFROM | ARCH PHARMALABS LTD (IN) | 2012-09-19 | — | — | EP | disclosed |
| US-8163959-B2 | Reacting 2-halo-1-(4-fluorophenyl)-2-phenone of formula II with 4-methyl-3-oxo-N-phenylpentamide; high purity and good yield; for the synthesis of atorvastatin | ARCH PHARMALABS LIMITED (IN) | 2012-04-24 | — | — | US | disclosed |
| US-20110060164-A1 | Reacting 2-halo-1-(4-fluorophenyl)-2-phenone of formula II with 4-methyl-3-oxo-N-phenylpentamide; high purity and good yield; for the synthesis of atorvastatin | ARCH PHARMALABS LIMITTED (IN) | 2011-03-10 | — | — | US | disclosed |
| EP-2279167-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-FLUORO-ALPHA-Ý2-METHYL -1-OXOPROPYL¨-GAMMA-OXO-N-ß-DIPHENYLBENZENEBUTANAMIDE AND PRODUCTS THEREFROM | Arch Pharmalabs Limited (IN) | 2011-02-02 | — | — | EP | disclosed |
| US-7872154-B2 | Method for the preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-y-oxo-n-β-diphenylbenzenebutanamide and products therefrom | ARCH PHARMALABS LIMITED (IN) | 2011-01-18 | — | — | US | disclosed |
| US-7872154-B2 | Method for the preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-y-oxo-n-β-diphenylbenzenebutanamide and products therefrom | ARCH PHARMALABS LIMITED (IN) | 2011-01-18 | — | — | US | disclosed |
| US-7872154-B2 | Method for the preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-y-oxo-n-β-diphenylbenzenebutanamide and products therefrom | ARCH PHARMALABS LIMITED (IN) | 2011-01-18 | — | — | US | disclosed |
| US-20090298907-A1 | METHOD FOR THE PREPARATION OF 4-FLUORO-ALPHA-[2-METHYL-1-OXOPROPYL]-y-OXO-N-BETA-DIPHENYLBENZENEBUTANAMIDE AND PRODUCTS THEREFROM | ARCH PHARMALABS LIMITED (IN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298907-A1 | METHOD FOR THE PREPARATION OF 4-FLUORO-ALPHA-[2-METHYL-1-OXOPROPYL]-y-OXO-N-BETA-DIPHENYLBENZENEBUTANAMIDE AND PRODUCTS THEREFROM | ARCH PHARMALABS LIMITED (IN) | 2009-12-03 | — | — | US | disclosed |
| EP-1644319-A4 | NOVEL HALO-SUBSTITUTED ACTIVE METHYLENE COMPOUNDS | BIOCON LTD (IN) | 2007-10-31 | — | — | EP | disclosed |
| US-20070249865-A1 | Process for Preparation of 4-Fluoro-Alpha-[2-Methyl-1-Oxopropyl]-Gamma-Oxo-N-Beta- Diphenylbenzene Butane Amide | BIOCON LIMITED (IN) | 2007-10-25 | — | — | US | disclosed |
| US-20070249865-A1 | Process for Preparation of 4-Fluoro-Alpha-[2-Methyl-1-Oxopropyl]-Gamma-Oxo-N-Beta- Diphenylbenzene Butane Amide | BIOCON LIMITED (IN) | 2007-10-25 | — | — | US | disclosed |
| US-20070249865-A1 | Process for Preparation of 4-Fluoro-Alpha-[2-Methyl-1-Oxopropyl]-Gamma-Oxo-N-Beta- Diphenylbenzene Butane Amide | BIOCON LIMITED (IN) | 2007-10-25 | — | — | US | disclosed |
| EP-1784384-A1 | PROCESS FOR PREPARATION OF 4-FLUORO-ALPHA-[2-METHYL-1-OXOPROPYL]GAMMA-OXO-N-BETA-DIPHENYLBENZENE BUTANE AMIDE | Biocon Limited (IN) | 2007-05-16 | — | — | EP | disclosed |
| US-7179942-B2 | Halo-substituted active methylene compounds | BICON LIMITED | 2007-02-20 | — | — | US | disclosed |
| EP-1644319-A1 | NOVEL HALO-SUBSTITUTED ACTIVE METHYLENE COMPOUNDS | Biocon Limited (IN) | 2006-04-12 | — | — | EP | disclosed |
| WO-2006021968-A1 | PROCESS FOR PREPARATION OF 4-FLUORO-α-[2-METHYL-1-OXOPROPYL]Ϝ-OXO-N-β-DIPHENYLBENZENE BUTANE AMIDE | BIOCON LIMITED (IN) | 2006-03-02 | — | — | WO | disclosed |
| US-20050113607-A1 | Novel halo-substituted active methylene compounds | BIOCON LIMITED | 2005-05-26 | — | — | US | disclosed |
| WO-2004108660-A1 | NOVEL HALO-SUBSTITUTED ACTIVE METHYLENE COMPOUNDS | BIOCON LIMITED (IN) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113607-A1 | Novel halo-substituted active methylene compounds | MRPL21, MAGI3, MGMT | ALDH1A1 1127/4885MAPT 4068/4885MEN1 506/4885 |
| US-20070249865-A1 | Process for Preparation of 4-Fluoro-Alpha-[2-Methyl-1-Oxopropyl]-Gamma-Oxo-N-Beta- Diphenylbenzene Butane Amide | CYP8B1, FGB, FLNB | ALDH1A1 731/4885MAPT 2067/4885MEN1 3582/4885 |
| US-20090298907-A1 | METHOD FOR THE PREPARATION OF 4-FLUORO-ALPHA-[2-METHYL-1-OXOPROPYL]-y-OXO-N-BETA-DIPHENYLBENZENEBUTANAMIDE AND PRODUCTS THEREFROM | NEFM, BPGM, HADHB | ALDH1A1 314/4885MAPT 2683/4885MEN1 3822/4885 |
| US-20110060164-A1 | Reacting 2-halo-1-(4-fluorophenyl)-2-phenone of formula II with 4-methyl-3-oxo-N-phenylpentamide; high purity and good yield; for the synthesis of atorvastatin | HMGCR, TGFB1, HSD17B12 | ALDH1A1 1023/4885MAPT 2352/4885MEN1 3079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.