Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.31 |
| ▸ | SDCBP | O00560 | 1/20 | 0.31 |
| ▸ | SDC2 | P34741 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9190169 | 0.71 | LMNA (0.36) | CYP11B1CYP11B2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL4466267 | 0.69 | LMNA (0.41) | CYP11B1CYP11B2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL2954267 | 0.67 | ALDH1A1 (0.41) | CYP11B1CYP11B2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL13237699 | 0.67 | ALDH1A1 (0.41) | CYP11B1CYP11B2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL7439509 | 0.66 | RAB9A (0.67) | CYP11B1CYP11B2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL3839962 | 0.62 | ALDH1A1 (0.42) | CYP11B1CYP11B2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL9188549 | 0.62 | HPGD (0.42) | CYP11B1CYP11B2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL4471060 | 0.59 | MEN1 (0.51) | ALDH1A1RAB9AHSD17B10MEN1KMT2A | |
| SCHEMBL16269466 | 0.59 | CYP11B1 (0.52) | CYP11B1CYP11B2 | |
| SCHEMBL4477266 | 0.58 | KDM4E (0.45) | ALDH1A1RAB9AHSD17B10MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576475-B1 | ISOINDOLES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO SPA (IT) | 1995-09-20 | — | — | EP | disclosed |
| US-5376673-A | Vasodilation | ITALFARMACO S.P.A. (IT) | 1994-12-27 | — | — | US | disclosed |