Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9188541 | 0.86 | KDM4E (0.37) | LMNAHPGDKDM4EPOLBALOX15 | |
| SCHEMBL9184179 | 0.82 | L3MBTL1 (0.52) | LMNAHPGDKDM4EPOLBALOX15 | |
| SCHEMBL9188549 | 0.78 | HPGD (0.42) | LMNAHPGDKDM4EPOLBALOX15 | |
| SCHEMBL9185538 | 0.75 | L3MBTL1 (0.50) | LMNAHPGDL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL10911693 | 0.74 | ACHE (0.42) | LMNAKDM4EPOLBALDH1A1RAB9A | |
| SCHEMBL9183908 | 0.73 | L3MBTL1 (0.48) | LMNAHPGDL3MBTL1ALDH1A1PTGS2 | |
| SCHEMBL4466267 | 0.71 | LMNA (0.41) | LMNAHPGDKDM4EPOLBALOX15 | |
| SCHEMBL9266701 | 0.71 | CYP11B1 (0.33) | LMNAHPGDALDH1A1RAB9AHSD17B10 | |
| SCHEMBL9166368 | 0.70 | ACHE (0.32) | LMNAPOLBL3MBTL1ALDH1A1PTGS2 | |
| SCHEMBL10909875 | 0.69 | POLB (0.44) | LMNAKDM4EPOLBALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576475-B1 | ISOINDOLES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO SPA (IT) | 1995-09-20 | — | — | EP | disclosed |
| US-5376673-A | Vasodilation | ITALFARMACO S.P.A. (IT) | 1994-12-27 | — | — | US | disclosed |
| EP-0576475-A1 | ISOINDOLES HAVING CARDIOVASCULAR ACTIVITY. | ITALFARMACO SPA (IT) | 1994-01-05 | — | — | EP | disclosed |
| WO-1992016506-A1 | ISOINDOLES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO S.P.A. (IT) | 1992-10-01 | — | — | WO | disclosed |