Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265637 | 0.84 | GSTP1 (0.51) | SLC2A1GSTP1TSHRCYP1A2CYP3A4 | |
| SCHEMBL9268241 | 0.83 | SLC2A1 (0.63) | SLC2A1HPGDPTGS2TSHRCYP1A2 | |
| SCHEMBL9262847 | 0.80 | PTGS2 (0.44) | SLC2A1PTGS2KDM4E | |
| SCHEMBL9267476 | 0.80 | MAPT (0.46) | SLC2A1PTGS2MAPTRAB9A | |
| SCHEMBL9454898 | 0.79 | ALDH1A1 (0.51) | HPGDALDH1A1PTGS2ATMKDM4E | |
| SCHEMBL9455121 | 0.75 | ALDH1A1 (0.46) | HPGDALDH1A1PTGS2CYP1A2KDM4E | |
| SCHEMBL9255564 | 0.75 | ACHE (0.41) | HPGDALDH1A1PTGS2KDM4EGAA | |
| SCHEMBL9267616 | 0.75 | SLC2A1 (0.39) | SLC2A1GSTP1PTGS2KDM4E | |
| SCHEMBL9455077 | 0.72 | KEAP1 (0.49) | PTGS2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL9269889 | 0.72 | PDGFRA (0.49) | HPGDALDH1A1PTGS2HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5403934-A | Heterocyclic compounds | BURROUGHS WELLCOME CO. (US) | 1995-04-04 | — | — | US | disclosed |
| WO-1991013873-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |
| EP-0447164-A1 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-18 | — | — | EP | disclosed |