Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7910336 | 0.71 | SLC9A1 (0.48) | ADRA2AADRA2BADRA2CSLC9A1NPC1 | |
| SCHEMBL7916809 | 0.68 | SLC9A1 (0.45) | SLC9A1NPC1RAB9APOLBKDM4E | |
| SCHEMBL927183 | 0.68 | SLC9A1 (0.45) | SLC9A1NPC1RAB9APOLBKDM4E | |
| SCHEMBL7916794 | 0.68 | SLC9A1 (0.61) | SLC9A1NPC1RAB9APOLBKDM4E | |
| SCHEMBL927184 | 0.68 | SLC9A1 (0.61) | SLC9A1NPC1RAB9APOLBKDM4E | |
| SCHEMBL3993813 | 0.68 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CSLC9A1NPC1 | |
| SCHEMBL927562 | 0.67 | ADRA2A (0.35) | ADRA2AADRA2BADRA2CSLC9A1 | |
| SCHEMBL29649376 | 0.67 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CSLC9A1NPC1 | |
| SCHEMBL18248744 | 0.67 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CSLC9A1NPC1 | |
| SCHEMBL7910258 | 0.67 | SLC9A1 (0.41) | ADRA2AADRA2BADRA2CSLC9A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875625-B2 | 3-guanidinocarbonyl-2-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ylmethyl hydrogen sulfate, inhibitory effect on an Na+/H+ exchanger; | TOA EIYO LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| US-20090012114-A1 | Cyclohepta[B]Pyridine-3-Carbonylguanidine Derivative and Pharmaceutical Product Containing Same | TOA EIYO LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012114-A1 | Cyclohepta[B]Pyridine-3-Carbonylguanidine Derivative and Pharmaceutical Product Containing Same | SLC10A6, SLC26A3, SLC9A3 | ADRA2A 350/4885ADRA2B 252/4885ADRA2C 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.