Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720060 | 0.83 | GAA (0.40) | L3MBTL1PDPK1AXLGAAMAPT | |
| SCHEMBL8717181 | 0.76 | PDPK1 (0.33) | PDPK1AXL | |
| SCHEMBL7544982 | 0.69 | KDR (0.54) | ALDH1A1L3MBTL1PDPK1TYMSNPY5R | |
| SCHEMBL4983900 | 0.69 | KDM4E (0.46) | ALDH1A1PDPK1AXLTYMSKDM4E | |
| SCHEMBL4484831 | 0.66 | PIK3CA (0.43) | ALDH1A1L3MBTL1POLBGAAKMT2A | |
| SCHEMBL14335487 | 0.64 | TOP2A (0.44) | ALDH1A1L3MBTL1TYMSNPY5RHPGD | |
| SCHEMBL4692166 | 0.64 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1NPY5RHPGDKDM4E | |
| SCHEMBL20256145 | 0.63 | HTR4 (0.36) | L3MBTL1TYMSNPY5RHPGDKDM4E | |
| SCHEMBL19046668 | 0.63 | NPY5R (0.41) | ALDH1A1L3MBTL1TYMSNPY5RHPGD | |
| SCHEMBL19044531 | 0.63 | NPY5R (0.41) | ALDH1A1TYMSNPY5RHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425650-B1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES | FISONS PLC (GB) | 1995-08-09 | — | — | EP | claimed |
| EP-0127389-B1 | N,N-DIETHYL-5-METHYL-2H-1-BENZOTHIOPYRANO-(4,3,2-CD)-INDAZOLE-2-ETHANAMINE, COMPOSITIONS COMPRISING THE SAME AND USES THEREFOR | WARNER-LAMBERT COMPANY (US) | 1988-09-07 | — | — | EP | claimed |
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | claimed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | claimed |
| EP-0425650-B1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES | FISONS PLC (GB) | 1995-08-09 | — | — | EP | disclosed |
| EP-0497809-B1 | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER MANNHEIM ITALIA (IT) | 1995-06-28 | — | — | EP | disclosed |
| US-5162320-A | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| EP-0172632-B1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| EP-0127389-B1 | N,N-DIETHYL-5-METHYL-2H-1-BENZOTHIOPYRANO-(4,3,2-CD)-INDAZOLE-2-ETHANAMINE, COMPOSITIONS COMPRISING THE SAME AND USES THEREFOR | WARNER-LAMBERT COMPANY (US) | 1988-09-07 | — | — | EP | disclosed |
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | disclosed |
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |