Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278847 | 0.77 | KDM4E (0.52) | MEN1KMT2AL3MBTL1KDM4EMAPT | |
| SCHEMBL9275026 | 0.76 | MAPT (0.37) | MEN1KMT2ALMNAL3MBTL1KDM4E | |
| SCHEMBL9274009 | 0.74 | MAPT (0.34) | MEN1KMT2ACYP2A6HTTMAPT | |
| SCHEMBL9279745 | 0.73 | KDM4E (0.45) | MEN1KMT2ALMNAL3MBTL1KDM4E | |
| SCHEMBL9281258 | 0.73 | L3MBTL1 (0.51) | MEN1KMT2AL3MBTL1KDM4EMAPT | |
| SCHEMBL4763744 | 0.73 | MKNK1 (0.43) | MKNK1MKNK2CYP2A6LMNAL3MBTL1 | |
| SCHEMBL6960011 | 0.72 | ALDH1A1 (0.54) | MEN1KMT2AMAPTTDP1 | |
| SCHEMBL6960006 | 0.72 | ALDH1A1 (0.54) | MEN1KMT2AMAPTTDP1 | |
| SCHEMBL14941196 | 0.71 | LDHA (0.41) | MEN1KMT2AL3MBTL1HTTKMO | |
| SCHEMBL3757392 | 0.70 | LMNA (0.56) | MKNK1MKNK2CYP2A6LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012050884-A2 | CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-04-19 | — | — | WO | claimed |
| EP-2646107-A2 | AGENT DELIVERY SYSTEMS FOR SELECTIVE NEUROMODULATION | Spinal Modulation Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012174537-A2 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012075337-A2 | DIRECTED DELIVERY OF AGENTS TO NEURAL ANATOMY | SPINAL MODULATION, INC. (US) | 2012-06-07 | — | — | WO | disclosed |