Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Icopezil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Icopezil SCHEMBL9276204 | 1.00 | ACHE (0.93) | ACHEBCHE | |
| Icopezil SCHEMBL3339253 | 0.96 | ACHE (1.00) | ACHEBCHE | |
| Icopezil SCHEMBL2231222 | 0.96 | ACHE (1.00) | ACHEBCHE | |
| Icopezil SCHEMBL194482 | 0.91 | ACHE (1.00) | ACHEBCHE | |
| SCHEMBL4512593 | 0.87 | ACHE (1.00) | ACHEBCHE | |
| SCHEMBL2402320 | 0.86 | ACHE (0.90) | ACHEBCHE | |
| Maleic Acid SCHEMBL3926936 | 0.84 | ACHE (0.77) | ACHEBCHE | |
| SCHEMBL220485 | 0.83 | ACHE (1.00) | ACHEBCHE | |
| SCHEMBL2405514 | 0.82 | ACHE (0.84) | ACHEBCHE | |
| SCHEMBL2403486 | 0.82 | ACHE (0.82) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646115-A1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-04-05 | — | — | EP | disclosed |