Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | AGO2 | Q9UKV8 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL8067192 | 0.89 | TSHR (0.61) | TSHRALDH1A1NT5EKMT2ALMNA | |
| Aniline SCHEMBL11429513 | 0.86 | TSHR (0.65) | TSHRALDH1A1KMT2AMEN1CYP3A4 | |
| Aniline SCHEMBL11429518 | 0.86 | TSHR (0.65) | TSHRALDH1A1KMT2AMEN1CYP3A4 | |
| Aniline SCHEMBL5693989 | 0.84 | TSHR (0.55) | TSHRALDH1A1NT5EKMT2ALMNA | |
| Aniline SCHEMBL28037885 | 0.84 | TSHR (0.61) | TSHRALDH1A1NT5EKMT2ALMNA | |
| Aniline SCHEMBL5831365 | 0.79 | TSHR (0.55) | TSHRALDH1A1NT5EKMT2ALMNA | |
| Questiomycin B SCHEMBL11559063 | 0.78 | ALOX15 (0.58) | TSHRALDH1A1KMT2ALMNAMEN1 | |
| Aniline SCHEMBL29494699 | 0.77 | TSHR (0.58) | TSHRALDH1A1KMT2AMEN1CYP3A4 | |
| Aniline SCHEMBL676147 | 0.76 | TSHR (0.65) | TSHRALDH1A1NT5EKMT2ALMNA | |
| Aniline SCHEMBL167326 | 0.76 | TSHR (0.65) | TSHRALDH1A1NT5EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5460936-A | With specific iodide content | KONICA CORPORATION (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5310641-A | Inner core, plurlity of outer shells substantially containing silver bromide or iodobromide; high speed, graininess, sharp, low fog density; astronomical, indoor, sports photography | KONICA CORPORATION (JP) | 1994-05-10 | — | — | US | disclosed |
| US-5221599-A | SILVER HALIDE PHOTOGRAPHIC LIGHT SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1993-06-22 | — | — | US | disclosed |
| US-4990437-A | With specific magenta coupler and core/shell silver halide grains | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1991-02-05 | — | — | US | disclosed |