Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628898 | 0.75 | IMPDH2 (0.55) | IMPDH2AHRALDH1A1MAPTKDM4E | |
| SCHEMBL29259140 | 0.73 | KIF11 (0.45) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL17383846 | 0.73 | IMPDH2 (0.73) | IMPDH2AHRALDH1A1MAPTKDM4E | |
| SCHEMBL6753454 | 0.72 | MEN1 (0.41) | AHRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL18392175 | 0.72 | CCR6 (0.58) | IMPDH2AHRALDH1A1MAPTKDM4E | |
| SCHEMBL30277945 | 0.71 | LMNA (0.53) | IMPDH2AHRALDH1A1MAPTKDM4E | |
| SCHEMBL16169793 | 0.70 | IMPDH2 (0.69) | IMPDH2AHRALDH1A1MAPTKDM4E | |
| SCHEMBL29678164 | 0.70 | IMPDH2 (0.58) | IMPDH2AHRALDH1A1MAPTKDM4E | |
| SCHEMBL2013427 | 0.69 | IMPDH2 (0.62) | IMPDH2AHRALDH1A1MAPTKDM4E | |
| SCHEMBL8722153 | 0.68 | IMPDH2 (0.65) | IMPDH2AHRALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651750-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-10 | — | — | EP | disclosed |