Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TARDBP | Q13148 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.57 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cmx-2043 SCHEMBL9273271 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| Cmx-2043 SCHEMBL8531623 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| Cmx-2043 SCHEMBL9282164 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| Cmx-2043 SCHEMBL9280271 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| Cmx-2043 SCHEMBL18078286 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| Cmx-2043 SCHEMBL13064768 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| Cmx-2043 SCHEMBL15865533 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| Cmx-2043 SCHEMBL15865534 | 1.00 | ACHE (0.57) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| SCHEMBL17265752 | 0.95 | HSD17B10 (0.61) | ACHEHSD17B10KMT2ATARDBPCYP2C9 | |
| SCHEMBL26804183 | 0.95 | HSD17B10 (0.61) | ACHEHSD17B10KMT2ATARDBPCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540417-B2 | Compositions and methods for treating ischemia and ischemia-reperfusion injury | ISCHEMIX LLC (US) | 2017-01-10 | — | — | US | disclosed |
| US-20160264622-A1 | Compositions And Methods For Treating Ischemia And Ischemia-Reperfusion Injury | ISCHEMIX LLC | 2016-09-15 | — | — | US | disclosed |
| US-20140274917-A1 | Compositions and Methods for Treating Ischemia and Ischemia-Reperfusion Injury | ISCHEMIX LLC (US) | 2014-09-18 | — | — | US | disclosed |
| US-8772249-B2 | Compositions and methods for treating ischemia and ischemia-reperfusion injury | Ischemix, LLC (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772250-B2 | Compositions and methods for treating ischemia and ischemia-reperfusion injury | Ischemix, LLC (US) | 2014-07-08 | — | — | US | disclosed |
| US-20120135932-A1 | Compositions And Methods For Treating Ischemia And Ischemia-Reperfusion Injury | ISCHEMIX LLC | 2012-05-31 | — | — | US | disclosed |
| US-20110160294-A1 | COMPOSITIONS AND METHODS FOR TREATING ISCHEMIA AND ISCHEMIA-REPERFUSION INJURY | ISCHEMIX LLC (US) | 2011-06-30 | — | — | US | disclosed |
| US-7928067-B2 | Compositions and methods for treating ischemia and ischemia-reperfusion injury | ISCHEMIX LLC (US) | 2011-04-19 | — | — | US | disclosed |
| US-7928067-B2 | Compositions and methods for treating ischemia and ischemia-reperfusion injury | ISCHEMIX LLC (US) | 2011-04-19 | — | — | US | disclosed |
| WO-2010132657-A1 | COMPOSITIONS AND METHODS FOR TREATING ISCHEMIA AND ISCHEMIA-REPERFUSION INJURY | ISCHEMIX LLC (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292313-A1 | COMPOSITIONS AND METHODS FOR TREATING ISCHEMIA AND ISCHEMIA-REPERFUSION INJURY | ISCHEMIX LLC | 2010-11-18 | — | — | US | disclosed |
| US-20100292313-A1 | COMPOSITIONS AND METHODS FOR TREATING ISCHEMIA AND ISCHEMIA-REPERFUSION INJURY | ISCHEMIX LLC | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292313-A1 | COMPOSITIONS AND METHODS FOR TREATING ISCHEMIA AND ISCHEMIA-REPERFUSION INJURY | PCK2, TNNI3, PINK1 | ACHE 4068/4885HSD17B10 2309/4885KMT2A 4571/4885 |
| US-20160264622-A1 | Compositions And Methods For Treating Ischemia And Ischemia-Reperfusion Injury | TNNI3, PCK2, AIFM1 | ACHE 3997/4885HSD17B10 2268/4885KMT2A 4768/4885 |
| US-20110160294-A1 | COMPOSITIONS AND METHODS FOR TREATING ISCHEMIA AND ISCHEMIA-REPERFUSION INJURY | TNNI3, PCK2, AIFM1 | ACHE 3997/4885HSD17B10 2268/4885KMT2A 4768/4885 |
| US-20140274917-A1 | Compositions and Methods for Treating Ischemia and Ischemia-Reperfusion Injury | TNNI3, PCK2, AIFM1 | ACHE 3997/4885HSD17B10 2268/4885KMT2A 4768/4885 |
| US-20120135932-A1 | Compositions And Methods For Treating Ischemia And Ischemia-Reperfusion Injury | TNNI3, TXN2, AIFM1 | ACHE 1675/4885HSD17B10 3106/4885KMT2A 4569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.