Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 9/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9275736 | 0.81 | ALK (0.65) | ALKPDPK1 | |
| SCHEMBL9887917 | 0.76 | CDK2 (0.52) | CLK1DYRK1ACDK2PLK4AURKA | |
| SCHEMBL9888167 | 0.71 | ALK (0.63) | ALKPDPK1 | |
| SCHEMBL21417195 | 0.69 | ITK (0.57) | DYRK1ACDK2PLK4AURKAJAK2 | |
| SCHEMBL31326342 | 0.68 | HTR6 (0.52) | CLK1DYRK1ASNCA | |
| SCHEMBL9888174 | 0.67 | ALK (0.59) | ALKPDPK1 | |
| SCHEMBL858197 | 0.67 | BRAF (0.53) | DYRK1ACDK2PLK4AURKAJAK2 | |
| SCHEMBL15253931 | 0.66 | ALK (0.65) | ALKPDPK1MET | |
| SCHEMBL15257736 | 0.65 | CDK2 (0.46) | DYRK1ACDK2PLK4AURKAJAK2 | |
| SCHEMBL28685666 | 0.64 | MET (0.51) | DYRK1ACDK2PLK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646438-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | Merck Patent GmbH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-09-19 | — | — | US | disclosed |
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-09-19 | — | — | US | disclosed |
| CN-103228657-A | 3-heteroaryl-substituted pyrrolo [2,3-b ] pyridine derivatives as PDK1 inhibitors | MERCK PATENT GMBH | 2013-07-31 | — | — | CN | disclosed |
| WO-2012072200-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012072200-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | PDK1, PDK2, PDK3 | CLK1 817/4885DYRK1A 650/4885CDK2 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.