Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.52 |
| ▸ | CDC7 | O00311 | 5/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15257736 | 0.88 | CDK2 (0.46) | CDK2CDC7CCNE1DBF4DYRK1A | |
| SCHEMBL9277787 | 0.81 | ALK (0.65) | ALKMETPDPK1 | |
| SCHEMBL9280778 | 0.76 | CLK1 (0.46) | CDK2CDC7CCNE1DBF4DYRK1A | |
| SCHEMBL9888186 | 0.71 | ALK (0.63) | ALKPDPK1 | |
| SCHEMBL31326342 | 0.70 | HTR6 (0.52) | DYRK1ACLK1SNCA | |
| SCHEMBL7955873 | 0.70 | CDK2 (0.55) | CDK2CDC7CCNE1DBF4DYRK1A | |
| SCHEMBL15257725 | 0.68 | PLK4 (0.55) | CDK2DYRK1ACDK1PLK4AURKA | |
| SCHEMBL7946423 | 0.68 | CDC7 (1.00) | CDK2CDC7CCNE1DBF4DYRK1A | |
| SCHEMBL9888177 | 0.67 | ALK (0.59) | ALKPDPK1 | |
| SCHEMBL14335342 | 0.67 | CDC7 (0.65) | CDK2CDC7CCNE1DBF4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-09-19 | — | — | US | disclosed |
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-09-19 | — | — | US | disclosed |
| CN-103228657-A | 3-heteroaryl-substituted pyrrolo [2,3-b ] pyridine derivatives as PDK1 inhibitors | MERCK PATENT GMBH | 2013-07-31 | — | — | CN | disclosed |
| WO-2012072200-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245355-A1 | 3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS | PDK1, PDK2, PDK3 | CDK2 43/4885CDC7 383/4885CCNE1 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.