SCHEMBL9280950

SCHEMBL9280950

NCC(O)c1ccccc1Oc1ccccc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.40
PNMT P11086 1/20 0.40
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
LTA4H P09960 1/20 0.37
PTGS2 P35354 1/20 0.37
IDO1 P14902 3/20 0.37
AR P10275 1/20 0.36
ADRA2A P08913 1/20 0.36
ADRA1A P35348 1/20 0.36
THRA P10827 1/20 0.36
THRB P10828 1/20 0.36
SCN9A Q15858 1/20 0.35
TDO2 P48775 1/20 0.35
MRGPRX4 Q96LA9 1/20 0.35
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ACP3 P15309 1/20 0.35
CNR2 P34972 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7148448 0.81 PNMT (0.47) PNMTIDO1ADRA2AADRA1ATDO2
SCHEMBL163013 0.81 PNMT (0.47) PNMTIDO1ADRA2AADRA1ATDO2
SCHEMBL1685381 0.77 LTA4H (0.46) PPARGRXRARXRBRXRGLTA4H
SCHEMBL11408986 0.77 AR (0.56) PPARGLTA4HPTGS2ARADRA2A
SCHEMBL11048002 0.75 LTA4H (0.45) PPARGRXRARXRBRXRGLTA4H
SCHEMBL14164518 0.75 HRH1 (0.49) ADRA2AADRA1AHPGDSMN1; SMN2SLC6A4
SCHEMBL768479 0.73 ALOX15 (0.56) PPARGRXRARXRBRXRGSCN9A
SCHEMBL768480 0.73 ALOX15 (0.56) PPARGRXRARXRBRXRGSCN9A
SCHEMBL30317544 0.72 ADRA2A (0.62) IDO1ADRA2AADRA1ATDO2
SCHEMBL7153423 0.72 ADRA2A (0.62) IDO1ADRA2AADRA1ATDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5514694-A ENZYME INHIBITORS GEORGIA TECH RESEARCH CORP (US) 1996-05-07 US disclosed
EP-0650368-A1 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY CORTEX PHARMACEUTICALS, INC. (US) 1995-05-03 EP disclosed
WO-1994000095-A2 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY CORTEX PHARMACEUTICALS, INC. (US) 1994-01-06 WO disclosed