Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.74 |
| ▸ | HTR1A | P08908 | 2/20 | 0.69 |
| ▸ | DRD4 | P21917 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10723708 | 0.85 | ALDH1A1 (0.85) | DRD2HTR1ADRD4ALDH1A1MAOA | |
| SCHEMBL7371815 | 0.81 | DRD2 (0.84) | DRD2HTR1ADRD4SLC6A4DRD3 | |
| Moclobemide SCHEMBL49708 | 0.79 | CD274 (1.00) | HTR1AALDH1A1MAOAMAOBKCNH2 | |
| Moclobemide SCHEMBL3408310 | 0.79 | CD274 (1.00) | HTR1AALDH1A1MAOAMAOBKCNH2 | |
| SCHEMBL14329888 | 0.79 | ALDH1A1 (0.94) | HTR1AALDH1A1MAOAMAOBKCNH2 | |
| Moclobemide SCHEMBL11475483 | 0.78 | CD274 (0.97) | HTR1AALDH1A1MAOAMAOBKCNH2 | |
| SCHEMBL10756632 | 0.77 | TMEM97 (0.72) | DRD2HTR1ADRD4ALDH1A1MAOA | |
| SCHEMBL1322020 | 0.77 | DRD4 (1.00) | DRD2HTR1ADRD4CYP1A2CYP3A4 | |
| SCHEMBL9387833 | 0.77 | ALDH1A1 (0.74) | DRD2HTR1AALDH1A1MAOAMAOB | |
| SCHEMBL30301397 | 0.77 | DRD2 (0.69) | DRD2HTR1ADRD4CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649419-A1 | N-CYCLOALKYLPIPERAZINE DERIVATIVES, METHODS OF OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES MERAM (FR) | 1995-04-26 | — | — | EP | disclosed |