Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599210 | 0.72 | ALDH1A1 (0.48) | ALDH1A1GAASMN1; SMN2LMNAHTT | |
| SCHEMBL9719342 | 0.71 | ALOX5 (0.47) | ALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL8805740 | 0.71 | MAPK1 (0.48) | ALDH1A1GAASMN1; SMN2LMNAHTT | |
| SCHEMBL9434703 | 0.70 | ALDH1A1 (0.55) | ALDH1A1MAPTGAAALOX12LMNA | |
| SCHEMBL9469385 | 0.70 | GAA (0.39) | ALDH1A1MAPTGAASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL9303053 | 0.69 | MAPK1 (0.55) | ALDH1A1MAPTGAAALOX12LMNA | |
| SCHEMBL9470503 | 0.68 | ALDH1A1 (0.40) | ALDH1A1MAPTGAASMN1; SMN2LMNA | |
| SCHEMBL9303463 | 0.68 | ALDH1A1 (0.44) | ALDH1A1MAPTGAAALOX12 | |
| SCHEMBL9302631 | 0.68 | ALDH1A1 (0.58) | ALDH1A1MAPTGAAALOX12SMN1; SMN2 | |
| SCHEMBL9434879 | 0.65 | ALDH1A1 (0.49) | ALDH1A1MAPTGAAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660833-A1 | 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO 2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006793-A1 | 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO[2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-03-31 | — | — | WO | disclosed |
| US-5278162-A | Learning enhancement | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-01-11 | — | — | US | disclosed |