Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9293371 | 0.75 | ALDH1A1 (0.34) | RXRARXRBALDH1A1NPC1PLA2G1B | |
| SCHEMBL9293202 | 0.74 | MEN1 (0.33) | PTPN5ALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL31754143 | 0.74 | KIF11 (0.45) | KIF11RXRARXRBPTAFRPTPN5 | |
| SCHEMBL25681766 | 0.72 | KIF11 (0.49) | KIF11RXRARXRBPTAFRPTPN5 | |
| SCHEMBL2365232 | 0.72 | CA2 (0.38) | ALDH1A1 | |
| SCHEMBL24870949 | 0.69 | KIF11 (0.46) | KIF11RXRARXRBPTAFRPTPN5 | |
| SCHEMBL30968570 | 0.69 | KIF11 (0.46) | KIF11RXRARXRBPTAFRPTPN5 | |
| SCHEMBL30023786 | 0.68 | KIF11 (0.72) | KIF11RXRARXRBPTPN5ALDH1A1 | |
| SCHEMBL5547288 | 0.68 | KIF11 (0.72) | KIF11RXRARXRBPTPN5ALDH1A1 | |
| SCHEMBL1680171 | 0.68 | NR1I2 (0.38) | KIF11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350846-A | Antibiotics | MERCK & CO., INC. (US) | 1994-09-27 | — | — | US | disclosed |
| US-5208329-A | Antibacterial agents | MERCK & CO., INC. (US) | 1993-05-04 | — | — | US | disclosed |
| US-5182385-A | Chemical intermediates for bactericides | MERCK & CO., INC. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0467434-A1 | 2-Biphenyl-carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-01-22 | — | — | EP | disclosed |
| EP-0464900-A2 | 2-Biphenyl-carbapenems | MERCK & CO. INC. (US) | 1992-01-08 | — | — | EP | disclosed |
| US-5025006-A | Carbapenicillin antibiotics | MERCK & CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |
| US-5011832-A | 2-biphenyl-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1991-04-30 | — | — | US | disclosed |