Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 16/20 | 0.60 |
| ▸ | NFE2L2 | Q16236 | 16/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 2/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | BACH1 | O14867 | 1/20 | 0.38 |
| ▸ | MAFK | O60675 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19998245 | 0.77 | ALDH1A2 (0.46) | KEAP1NFE2L2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12948853 | 0.77 | KMT2A (0.47) | KEAP1NFE2L2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13624926 | 0.76 | KEAP1 (0.62) | KEAP1NFE2L2KMT2AMIFNAAA | |
| SCHEMBL22917014 | 0.76 | KMT2A (0.57) | CYP2D6CYP2C9CYP2C19KMT2AALDH1A1 | |
| SCHEMBL861034 | 0.76 | KMT2A (0.57) | CYP2D6CYP2C9CYP2C19KMT2AALDH1A1 | |
| SCHEMBL23839910 | 0.74 | ALDH1A1 (0.58) | CYP2D6CYP2C9CYP2C19KMT2AALDH1A1 | |
| SCHEMBL23188735 | 0.74 | ALDH1A1 (0.58) | CYP2D6CYP2C9CYP2C19KMT2AALDH1A1 | |
| SCHEMBL17777241 | 0.74 | ALDH1A1 (0.58) | CYP2D6CYP2C9CYP2C19KMT2AALDH1A1 | |
| SCHEMBL81704 | 0.74 | KEAP1 (0.58) | KEAP1NFE2L2MIFNAAAALDH1A1 | |
| SCHEMBL17680116 | 0.73 | CYP2C19 (0.44) | CYP2D6CYP2C9CYP2C19KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129159-B2 | Attachment of molecules to surfaces | SURMODICS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110009292-A1 | ATTACHMENT OF MOLECULES TO SURFACES | SURMODICS, INC. (US) | 2011-01-13 | — | — | US | disclosed |
| US-7829317-B2 | Attachment of molecules to surfaces | SURMODICS, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20090042742-A1 | Attachment of molecules to surfaces | SURMODICS, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| US-7309593-B2 | Attachment of molecules to surfaces | SURMODICS, INC. (US) | 2007-12-18 | — | — | US | disclosed |