Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301439 | 0.88 | P2RY14 (0.78) | P2RY14ALOX5LTB4RLTB4R2MRGPRX4 | |
| SCHEMBL9300644 | 0.88 | P2RY14 (0.78) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9301058 | 0.85 | P2RY14 (0.73) | P2RY14ALOX5LTB4RLTB4R2MRGPRX4 | |
| SCHEMBL9301072 | 0.83 | P2RY14 (0.71) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL2933136 | 0.83 | P2RY14 (0.70) | P2RY14ALOX5LTB4RLTB4R2MRGPRX4 | |
| SCHEMBL9301210 | 0.81 | P2RY14 (0.68) | P2RY14MEN1KMT2AALOX5KDM4E | |
| SCHEMBL5921632 | 0.81 | MRGPRX4 (0.76) | P2RY14MEN1KMT2AALOX5MRGPRX4 | |
| Hydrochloric Acid SCHEMBL8380168 | 0.79 | MRGPRX4 (0.74) | P2RY14MEN1KMT2AALOX5MRGPRX4 | |
| SCHEMBL9302530 | 0.79 | P2RY14 (0.63) | P2RY14ALOX5MRGPRX4 | |
| SCHEMBL2934240 | 0.79 | P2RY14 (0.65) | P2RY14ALOX5LTB4RLTB4R2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |