Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.71 |
| ▸ | ALOX5 | P09917 | 11/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300510 | 0.83 | P2RY14 (1.00) | P2RY14ALOX5MAOBLTB4RLTB4R2 | |
| SCHEMBL9300644 | 0.81 | P2RY14 (0.78) | P2RY14ALOX5MAOBLTB4RLTB4R2 | |
| SCHEMBL9301912 | 0.81 | KDM4E (0.46) | P2RY14ALOX5MAOB | |
| SCHEMBL9301439 | 0.79 | P2RY14 (0.78) | P2RY14ALOX5MAOBLTB4RLTB4R2 | |
| SCHEMBL9301058 | 0.79 | P2RY14 (0.73) | P2RY14ALOX5MAOBLTB4RLTB4R2 | |
| SCHEMBL2931677 | 0.72 | P2RY14 (0.60) | P2RY14ALOX5MAOBLTB4RLTB4R2 | |
| SCHEMBL9301064 | 0.70 | ALOX5 (0.51) | P2RY14ALOX5MAOB | |
| SCHEMBL13057641 | 0.68 | MEN1 (0.57) | P2RY14MAOBLTB4RLTB4R2 | |
| SCHEMBL6087461 | 0.68 | ALOX5 (0.56) | P2RY14ALOX5MAOB | |
| SCHEMBL9301951 | 0.68 | P2RY14 (0.55) | P2RY14ALOX5MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |