Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CACNA1G | O43497 | 7/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 2/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301208 | 0.92 | CYP2D6 (0.61) | CYP2D6CACNA1GKCNH2PRMT5WDR77 | |
| SCHEMBL9189672 | 0.90 | CACNA1G (0.60) | CACNA1GKCNH2RECQLSMN1; SMN2TP53 | |
| SCHEMBL9301847 | 0.88 | CACNA1G (0.64) | CYP2D6CACNA1GKCNH2PRMT5WDR77 | |
| SCHEMBL9301814 | 0.86 | CYP2D6 (0.54) | CYP2D6CACNA1GKCNH2PRMT5WDR77 | |
| SCHEMBL9301158 | 0.84 | CACNA1G (0.67) | CYP2D6CACNA1GKCNH2SCN1ASCN5A | |
| SCHEMBL9192429 | 0.80 | KCNH2 (0.64) | CACNA1GKCNH2RECQLMAPT | |
| SCHEMBL9301487 | 0.79 | CYP2D6 (0.55) | CYP2D6CACNA1GKCNH2SCN1ASCN5A | |
| SCHEMBL9303300 | 0.78 | L3MBTL1 (0.70) | CYP2D6MAPT | |
| SCHEMBL10379764 | 0.78 | L3MBTL1 (0.62) | CYP2D6CACNA1GKCNH2MAPT | |
| SCHEMBL9300865 | 0.77 | KDM4E (0.53) | CACNA1GKCNH2SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| EP-0435902-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE. | BASF AG (DE) | 1991-07-10 | — | — | EP | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |