Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302474 | 0.86 | L3MBTL1 (0.64) | KDM4EPOLBMAPTMEN1KMT2A | |
| SCHEMBL9272796 | 0.82 | TP53 (0.50) | KDM4EPOLBMAPTMEN1KMT2A | |
| SCHEMBL9187274 | 0.79 | MAPT (0.60) | KDM4EMAPTMEN1KMT2AKCNH2 | |
| SCHEMBL9192429 | 0.79 | KCNH2 (0.64) | KDM4EMAPTKMT2AKCNH2MAPK1 | |
| SCHEMBL9301048 | 0.78 | MEN1 (0.53) | MAPTMEN1KMT2AKCNH2L3MBTL1 | |
| SCHEMBL9303300 | 0.77 | L3MBTL1 (0.70) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL9301602 | 0.76 | TSHR (0.64) | KDM4EMAPTMEN1KMT2AKCNH2 | |
| SCHEMBL9300891 | 0.76 | TSHR (0.64) | KDM4EMAPTMEN1KMT2AKCNH2 | |
| SCHEMBL9301630 | 0.76 | MAPT (0.55) | KDM4EMAPTMEN1KMT2AKCNH2 | |
| SCHEMBL9301397 | 0.76 | MAPT (0.57) | KDM4EMAPTMEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342839-A | Useful for therapy of oxygen deficiency diseases of the brain | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | disclosed |
| EP-0435902-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE. | BASF AG (DE) | 1991-07-10 | — | — | EP | disclosed |
| WO-1990003371-A1 | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINES AND HOMOPIPERAZINES, THEIR MANUFACTURE AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-05 | — | — | WO | disclosed |