Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301938 | 0.70 | DRD3 (0.43) | POLBMEN1KMT2AALDH1A1DRD3 | |
| SCHEMBL9302026 | 0.61 | DRD3 (0.44) | POLBMEN1KMT2AALDH1A1DRD3 | |
| SCHEMBL9302904 | 0.60 | ALDH1A1 (0.45) | SMN1; SMN2POLBMEN1THRBTSHR | |
| SCHEMBL14922282 | 0.57 | ALDH1A1 (0.51) | SMN1; SMN2POLBRECQLHSD17B10ALDH1A1 | |
| SCHEMBL2894409 | 0.57 | ALDH1A1 (0.60) | POLBRECQLKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL8253234 | 0.56 | HTR1A (0.47) | TSHRKMT2AL3MBTL1DRD3DRD2 | |
| SCHEMBL13382891 | 0.56 | DRD2 (0.53) | SMN1; SMN2POLBMEN1TSHRKMT2A | |
| SCHEMBL12714783 | 0.56 | ALDH1A1 (0.54) | POLBRECQLKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL28425579 | 0.56 | ALDH1A1 (0.54) | POLBRECQLKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL16514423 | 0.55 | ALDH1A1 (0.62) | POLBRECQLKMT2AHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283248-A | Bactericides, enzyme inhibitor of DNA-gyrase in bacteria | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |