Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751551 | 0.86 | MTNR1A (0.50) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| SCHEMBL9303475 | 0.83 | MTNR1A (0.72) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| SCHEMBL9303906 | 0.82 | MTNR1A (0.71) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| SCHEMBL9302872 | 0.82 | MTNR1A (0.71) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| Luzindole SCHEMBL4869000 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| SCHEMBL3060693 | 0.79 | MTNR1A (0.56) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| SCHEMBL9401161 | 0.77 | MTNR1A (0.84) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| SCHEMBL9303976 | 0.75 | MTNR1A (0.69) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| SCHEMBL9751553 | 0.74 | MTNR1A (0.79) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 | |
| Luzindole SCHEMBL9118261 | 0.74 | MEN1 (0.81) | MTNR1AMTNR1BCYP1A2TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283343-A | Melatonin antagonists | WHITBY RESEARCH, INC. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5093352-A | Melatonin inhibitor, sleep, 2-aryl N-acetyl tryptamine | WHITBY RESEARCH, INC. (US) | 1992-03-03 | — | — | US | disclosed |