SCHEMBL9303976

SCHEMBL9303976

CC(=O)NCCc1c(Cc2cccs2)[nH]c2ccccc12

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 12/20 0.69
MTNR1B P49286 12/20 0.69
CYP1A2 P05177 4/20 0.69
CYP2C19 P33261 4/20 0.69
CYP3A4 P08684 3/20 0.69
HPGD P15428 3/20 0.69
TSHR P16473 3/20 0.69
TDP1 Q9NUW8 3/20 0.69
CYP2C9 P11712 2/20 0.69
MEN1 O00255 2/20 0.69
KMT2A Q03164 2/20 0.69
ALDH1A1 P00352 2/20 0.51
CYP2D6 P10635 2/20 0.51
ALOX15 P16050 2/20 0.51
MAPT P10636 2/20 0.51
CHRNB2 P17787 1/20 0.46
CHRNA7 P36544 1/20 0.46
CHRNA4 P43681 1/20 0.46
KDM4E B2RXH2 1/20 0.46
HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29138467 0.86 MTNR1A (0.51) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL9751551 0.84 MTNR1A (0.50) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
Luzindole SCHEMBL4869000 0.82 MTNR1A (1.00) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL9401161 0.79 MTNR1A (0.84) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL9303475 0.79 MTNR1A (0.72) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL9751553 0.79 MTNR1A (0.79) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL29138488 0.78 EGFR (0.47) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL9303906 0.78 MTNR1A (0.71) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL9302872 0.78 MTNR1A (0.71) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4
SCHEMBL9302420 0.75 MTNR1A (0.65) MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5283343-A Melatonin antagonists WHITBY RESEARCH, INC. (US) 1994-02-01 US disclosed
US-5093352-A Melatonin inhibitor, sleep, 2-aryl N-acetyl tryptamine WHITBY RESEARCH, INC. (US) 1992-03-03 US disclosed