Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | IDO1 | P14902 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750364 | 0.86 | HDAC1 (0.73) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL9302460 | 0.84 | HDAC1 (0.71) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL13907295 | 0.83 | CYP11B1 (0.89) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL12850040 | 0.82 | HDAC6 (1.00) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL3497107 | 0.81 | HDAC1 (0.70) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL7672864 | 0.79 | CYP11B1 (0.75) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL9302833 | 0.79 | SMN1; SMN2 (0.73) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL3497641 | 0.79 | CYP11B1 (0.65) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL31357411 | 0.78 | CYP11B1 (1.00) | HDAC1HDAC6CYP11B1CYP11B2TNF | |
| SCHEMBL230002 | 0.78 | CYP11B1 (1.00) | HDAC1HDAC6CYP11B1CYP11B2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314880-A | Platelet activating factor antagonist | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | disclosed |