Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301506 | 0.81 | MAPT (0.38) | SIRT6ALDH1A1HTR6LMNACYP2D6 | |
| SCHEMBL8112311 | 0.74 | MAPT (0.39) | SIRT6ALDH1A1HPGDLMNACYP2D6 | |
| SCHEMBL8112070 | 0.72 | WDR5 (0.36) | SIRT6ALDH1A1HPGDCYP2D6CYP2C9 | |
| SCHEMBL22712825 | 0.69 | SIRT6 (0.60) | SIRT6ALDH1A1HTR6HRH4MET | |
| SCHEMBL9564453 | 0.68 | MAPT (0.48) | SIRT6ALDH1A1HTR6CYP2D6CYP2C9 | |
| SCHEMBL9302543 | 0.66 | MAPT (0.48) | SIRT6ALDH1A1LMNAACHEBCHE | |
| SCHEMBL10570306 | 0.66 | MAPT (0.51) | SIRT6ALDH1A1HTR6LMNACYP2D6 | |
| SCHEMBL9302194 | 0.66 | ACHE (0.39) | HTR6HRH4ACHEMETPDE5A | |
| SCHEMBL3147203 | 0.64 | SIRT6 (0.83) | SIRT6ALDH1A1HTR6CYP2C9 | |
| SCHEMBL1847175 | 0.64 | SIRT6 (1.00) | SIRT6ALDH1A1HTR6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283248-A | Bactericides, enzyme inhibitor of DNA-gyrase in bacteria | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |