SCHEMBL9302938

SCHEMBL9302938

O=C(O)N1CCN(c2cc(NC3CC3)c([N+](=O)[O-])cc2F)CC1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GPR174 Q9BXC1 10/20 0.54
MAPT P10636 7/20 0.52
ALDH1A1 P00352 3/20 0.52
SMN1; SMN2 Q16637 2/20 0.49
HCAR3 P49019 1/20 0.49
LMNA P02545 2/20 0.48
GAA P10253 1/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
MAPK1 P28482 2/20 0.48
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9302948 1.00 GPR174 (0.54) GPR174MAPTALDH1A1SMN1; SMN2HCAR3
SCHEMBL9302533 0.90 GPR174 (0.67) GPR174MAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL9301752 0.86 MAPT (0.62) GPR174MAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL21986291 0.85 HCAR3 (0.50) GPR174MAPTALDH1A1SMN1; SMN2HCAR3
SCHEMBL9303323 0.85 MAPT (0.54) GPR174MAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL9847727 0.84 GPR174 (0.43) GPR174MAPTALDH1A1SMN1; SMN2HCAR3
SCHEMBL9847853 0.83 MAPT (0.63) GPR174MAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL9847721 0.83 MAPT (0.56) GPR174MAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL29525723 0.77 MAPT (0.56) MAPTALDH1A1SMN1; SMN2HCAR3LMNA
SCHEMBL17896593 0.77 MAPT (0.56) MAPTALDH1A1SMN1; SMN2HCAR3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5283248-A Bactericides, enzyme inhibitor of DNA-gyrase in bacteria HOFFMANN-LA ROCHE INC. (US) 1994-02-01 US disclosed
EP-0433648-A1 Substituted pyrimidobenzimidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1991-06-26 EP disclosed