Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 3/20 | 0.44 |
| ▸ | LDHB | P07195 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | WEE1 | P30291 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585437 | 0.85 | NPC1 (0.51) | ALDH1A1KDM4ETSHRCYP3A4CYP2C9 | |
| SCHEMBL9391003 | 0.83 | GPR35 (0.40) | GAAKDM4EGFERLDHALDHB | |
| SCHEMBL9270518 | 0.82 | LDHA (0.40) | ERAP1ALDH1A1GAAKDM4EGFER | |
| SCHEMBL28184860 | 0.76 | PDE10A (0.47) | ALDH1A1GAAKDM4ELDHALDHB | |
| SCHEMBL28664927 | 0.76 | LDHA (0.49) | ALDH1A1GAAKDM4EGFERLDHA | |
| SCHEMBL338936 | 0.74 | DHODH (0.49) | ALDH1A1GAAKDM4EGFERTSHR | |
| SCHEMBL15013474 | 0.71 | DHODH (0.54) | GAATSHRLMNAMAPTFABP3 | |
| SCHEMBL901570 | 0.71 | DHODH (0.53) | ALDH1A1GAAKDM4EGFERLDHA | |
| SCHEMBL10832124 | 0.70 | PDE10A (0.50) | ALDH1A1GAAKDM4ETSHRCYP2C9 | |
| SCHEMBL5589911 | 0.69 | LDHA (0.45) | ALDH1A1GAAKDM4ELDHALDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |