Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | ESRRA | P11474 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303055 | 0.85 | ERAP1 (0.48) | MEN1KMT2AMAPTLMNAHPGD | |
| SCHEMBL9391003 | 0.78 | GPR35 (0.40) | CSNK2A2CSNK2BESR2KDM4E | |
| SCHEMBL9270518 | 0.77 | LDHA (0.40) | NPC1KMT2ATSHRCYP3A4CYP2C9 | |
| SCHEMBL9898347 | 0.71 | DHODH (0.50) | LMNAHPGDHSD17B10TSHRCYP2C9 | |
| SCHEMBL28664927 | 0.71 | LDHA (0.49) | MAPTLMNAHPGDSMN1; SMN2HTT | |
| SCHEMBL6652685 | 0.71 | KDM4E (0.49) | NPC1MEN1KMT2AMAPTLMNA | |
| SCHEMBL8353016 | 0.69 | SMN1; SMN2 (0.59) | HPGDSMN1; SMN2HSD17B10CYP2C9CYP2C19 | |
| SCHEMBL11253942 | 0.68 | HPGD (0.51) | NPC1MEN1KMT2AESRRAMAPT | |
| SCHEMBL6383991 | 0.68 | SMN1; SMN2 (0.54) | NPC1MAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL5427914 | 0.68 | NPC1 (1.00) | NPC1MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |