Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476707 | 0.91 | KDM4E (0.41) | HPGDALDH1A1KDM4EBRS3NPSR1 | |
| SCHEMBL5592930 | 0.86 | BRS3 (0.39) | HPGDALDH1A1KDM4ECRHBPCRHR2 | |
| SCHEMBL12475515 | 0.77 | BRS3 (0.45) | BRS3FFAR1AKR1B1AGTR1AGTR2 | |
| SCHEMBL9302784 | 0.75 | ALDH1A1 (0.35) | HPGDALDH1A1KDM4ECRHBPCRHR2 | |
| SCHEMBL3976315 | 0.75 | BRS3 (0.44) | BRS3FFAR1AKR1B1MMEAGTR1 | |
| SCHEMBL8357465 | 0.72 | BRS3 (0.45) | BRS3FFAR1AKR1B1AGTR1AGTR2 | |
| SCHEMBL3978313 | 0.71 | BRS3 (0.46) | BRS3FFAR1AKR1B1MMEAGTR1 | |
| SCHEMBL8635574 | 0.71 | FFAR1 (0.40) | ALDH1A1KDM4EBRS3FFAR1AKR1B1 | |
| SCHEMBL7376273 | 0.70 | BRS3 (0.42) | HPGDALDH1A1KDM4EBRS3NPSR1 | |
| SCHEMBL7008730 | 0.70 | ALDH1A1 (0.44) | HPGDALDH1A1KDM4ECRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354766-A | 2-Ethoxy-1-((2'(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl) biphenyl-4-yl)methyl)benzimidazole-7-carboxylic acid; hypotensive agents; CNS activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-11 | — | — | US | disclosed |