Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869620 | 0.93 | SIGMAR1 (0.49) | SIGMAR1SLC6A9SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9303707 | 0.84 | SCN1A (0.38) | SIGMAR1SLC6A4CYP3A4 | |
| SCHEMBL9304202 | 0.82 | SIGMAR1 (0.46) | SIGMAR1TMEM97 | |
| SCHEMBL9303673 | 0.81 | CNR2 (0.34) | SIGMAR1ADAM17CNR2TMEM97 | |
| SCHEMBL9304790 | 0.73 | TAAR1 (0.36) | SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL9304467 | 0.71 | UTS2R (0.35) | SIGMAR1ADAM17CNR2SLC6A9TMEM97 | |
| SCHEMBL9303403 | 0.69 | SLC6A2 (0.43) | SIGMAR1KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9467170 | 0.66 | TSHR (0.47) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11609001 | 0.64 | SCN1A (0.59) | SIGMAR1SLC6A4SLC6A2SLC6A3TMEM97 | |
| Hydrochloric Acid SCHEMBL11610444 | 0.64 | SIGMAR1 (0.49) | SIGMAR1SLC6A4SLC6A2SLC6A3TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0505379-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 1994-07-20 | — | — | EP | disclosed |
| US-5300516-A | Muscarinic receptor antagonists | PFIZER INC. (US) | 1994-04-05 | — | — | US | disclosed |