SCHEMBL9304320

SCHEMBL9304320

N=C(N)Nc1cccc(C(=O)Nc2cc3ccccc3cc2C(=N)N)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLAU P00749 7/20 0.50
F2 P00734 3/20 0.50
PLG P00747 3/20 0.50
PLAT P00750 3/20 0.50
KLKB1 P03952 2/20 0.50
PRSS1 P07477 2/20 0.50
PTGES O14684 1/20 0.50
KLK1 P06870 1/20 0.50
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
SIRT2 Q8IXJ6 2/20 0.46
F10 P00742 1/20 0.44
KCNK3 O14649 2/20 0.44
KCNK9 Q9NPC2 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
KDM4E B2RXH2 1/20 0.43
CASP3 P42574 1/20 0.43
SENP7 Q9BQF6 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9302612 0.87 PLAU (0.55) PLAUF2PLGPLATKLKB1
SCHEMBL9304048 0.86 SIRT2 (0.55) PLAUF2PLGPLATKLKB1
SCHEMBL9303936 0.84 PTGES (0.52) PLAUF2PLGPLATKLKB1
SCHEMBL9302845 0.81 PTGES (0.52) PLAUF2PLGPLATKLKB1
SCHEMBL9304163 0.81 PTGES (0.54) PLAUF2PLGPLATKLKB1
SCHEMBL9303515 0.81 PTGES (0.48) PLAUF2PLGPLATKLKB1
SCHEMBL9302930 0.81 PTGES (0.51) PLAUF2PLGPLATKLKB1
SCHEMBL9302840 0.81 PTGES (0.51) PLAUF2PLGPLATKLKB1
SCHEMBL9303308 0.80 PTGES (0.56) PTGESNPC1RAB9AMEN1KMT2A
SCHEMBL9304321 0.80 PLAU (0.50) PLAUF2PLGPLATKLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5352704-A Antiviral agents BANYU PHARMACEUTICAL CO., LTD. (JP) 1994-10-04 US disclosed
EP-0434432-B1 Guanidinobenzene derivatives BANYU PHARMA CO LTD (JP) 1994-05-04 EP disclosed
EP-0434432-A1 Guanidinobenzene derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1991-06-26 EP disclosed