SCHEMBL9305057

SCHEMBL9305057

O=C1c2ccccc2C(=O)N1Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.62
KMT2A Q03164 4/20 0.62
CYP1A2 P05177 1/20 0.62
CTDSP1 Q9GZU7 1/20 0.62
SCN2A Q99250 2/20 0.58
HPGD P15428 1/20 0.51
ALOX12 P18054 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
ALDH1A1 P00352 4/20 0.49
MAPT P10636 1/20 0.49
CXCR2 P25025 1/20 0.49
PTPN1 P18031 1/20 0.48
CDC25A P30304 1/20 0.48
CDC25B P30305 1/20 0.48
ALOX5 P09917 1/20 0.48
RECQL P46063 1/20 0.46
HSD17B10 Q99714 1/20 0.46
NPC1 O15118 1/20 0.44
MITF O75030 1/20 0.44
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9306130 0.83 MEN1 (0.66) MEN1KMT2ACYP1A2CTDSP1SCN2A
SCHEMBL3259551 0.78 CYP1A2 (1.00) MEN1KMT2ACYP1A2CTDSP1HPGD
SCHEMBL9303275 0.77 ALDH1A1 (0.50) MEN1KMT2AHPGDALOX12L3MBTL1
SCHEMBL11862182 0.77 MEN1 (1.00) MEN1KMT2ACYP1A2CTDSP1SCN2A
SCHEMBL14322059 0.77 CYP1A2 (0.74) MEN1KMT2ACYP1A2CTDSP1HPGD
SCHEMBL9304040 0.76 ALOX5 (0.79) MEN1KMT2ASCN2AHPGDALOX12
SCHEMBL266574 0.76 MEN1 (0.70) MEN1KMT2ACYP1A2CTDSP1SCN2A
Hydrochloric Acid SCHEMBL5138493 0.76 CYP1A2 (0.96) MEN1KMT2ACYP1A2CTDSP1HPGD
SCHEMBL133402 0.75 CYP1A2 (0.71) MEN1KMT2ACYP1A2CTDSP1HPGD
SCHEMBL9657352 0.75 CYP1A2 (0.71) MEN1KMT2ACYP1A2HPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0546113-A1 NONLINEAR OPTICAL MATERIALS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-06-16 EP claimed
WO-1992003417-A2 NONLINEAR OPTICAL MATERIALS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-03-05 WO claimed
US-5312565-A Nonlinear optical materials E. I. DUPONT DE NEMOURS AND COMPANY (US) 1994-05-17 US disclosed
EP-0546113-A1 NONLINEAR OPTICAL MATERIALS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-06-16 EP disclosed
WO-1992003417-A2 NONLINEAR OPTICAL MATERIALS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-03-05 WO disclosed