Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 4/20 | 0.33 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 2/20 | 0.33 |
| ▸ | KLK1 | P06870 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266916 | 0.70 | IMPDH2 (0.39) | IMPDH2GPR84MEN1CYP1A2CYP3A4 | |
| SCHEMBL14799966 | 0.69 | IMPDH2 (0.51) | IMPDH2GPR84ADORA2AMEN1CYP1A2 | |
| SCHEMBL114219 | 0.68 | ALDH1A1 (0.48) | CYP1A2CYP3A4ALDH1A1HSD17B10CYP2C19 | |
| SCHEMBL26259960 | 0.66 | IMPDH2 (0.60) | IMPDH2GPR84ADORA2AMEN1CYP1A2 | |
| SCHEMBL5485480 | 0.65 | ALDH1A1 (0.41) | ADORA2AMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL134135 | 0.65 | ALDH1A1 (0.40) | MEN1CYP1A2CYP3A4KMT2AALDH1A1 | |
| SCHEMBL396722 | 0.65 | — | — | |
| SCHEMBL28225781 | 0.65 | GPR84 (0.57) | IMPDH2GPR84ADORA2APLAUPLG | |
| SCHEMBL14134453 | 0.64 | IMPDH2 (0.47) | IMPDH2GPR84ADORA2APLAUPLG | |
| SCHEMBL578393 | 0.64 | ALDH1A1 (0.39) | CYP1A2CYP3A4ALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |