Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9307463 | 0.88 | KDM4E (0.53) | KDM4EMAPTKMT2AMEN1HTT | |
| SCHEMBL9153220 | 0.85 | ALOX5 (0.58) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL8200416 | 0.84 | PIM1 (0.49) | KDM4EMAPTKMT2AMEN1HTT | |
| SCHEMBL8784359 | 0.83 | KDM4E (0.64) | KDM4EMAPTKMT2AMEN1HTT | |
| SCHEMBL7116317 | 0.81 | PIM1 (0.54) | KDM4EMAPTKMT2AMEN1HTT | |
| SCHEMBL8784953 | 0.81 | MAOA (0.51) | KDM4EKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL11330155 | 0.76 | KDM4E (0.56) | KDM4EMAPTKMT2AMEN1HTT | |
| SCHEMBL9306580 | 0.76 | GABRP (0.55) | KDM4EKMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8784876 | 0.75 | MAP2 (0.48) | KDM4EMAPTHTTALDH1A1HPGD | |
| SCHEMBL9155007 | 0.74 | NQO1 (0.46) | KDM4EMAPTKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278186-A | Substituted with secondary amide | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-01-11 | — | — | US | disclosed |