Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9310760 | 0.87 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL9308093 | 0.84 | MRGPRX4 (0.51) | ALOX5KDM2BALDH1A1 | |
| SCHEMBL9309969 | 0.82 | ALOX5 (0.43) | ALOX5KDM2BALDH1A1 | |
| SCHEMBL9308523 | 0.81 | ALOX5 (0.62) | ALOX5CYP2D6HRH3 | |
| SCHEMBL9309603 | 0.79 | ALOX5 (0.60) | ALOX5CYP2D6HRH3 | |
| SCHEMBL9307868 | 0.79 | ALOX5 (0.62) | ALOX5 | |
| SCHEMBL9209013 | 0.78 | ALOX5 (0.81) | ALOX5 | |
| SCHEMBL9135429 | 0.78 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL9310396 | 0.77 | ALOX5 (0.63) | ALOX5 | |
| SCHEMBL9139351 | 0.77 | ALOX5 (1.00) | ALOX5CYP2D6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354865-A | Enzyme inhibitor and inhibiting the leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994005281-A1 | PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1994-03-17 | — | — | WO | disclosed |