Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9310079 | 0.87 | ALOX5 (0.45) | ALOX5BRPF1KDM4EALDH1A1KDM2B | |
| SCHEMBL9308116 | 0.83 | KMT2A (0.38) | KDM4EALDH1A1KDM2BMEN1MAPT | |
| SCHEMBL9307254 | 0.82 | ALOX5 (0.64) | ALOX5ALDH1A1KDM2B | |
| SCHEMBL9389965 | 0.79 | ALOX5 (0.40) | ALOX5BRPF1TRPV1 | |
| SCHEMBL9308141 | 0.78 | ALOX5 (0.47) | ALOX5BRPF1 | |
| SCHEMBL9310760 | 0.71 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL9308150 | 0.70 | MGLL (0.34) | KDM4EALDH1A1KDM2BHSD11B1L3MBTL1 | |
| SCHEMBL9309991 | 0.69 | ALOX5 (0.46) | ALOX5BRPF1 | |
| SCHEMBL8953781 | 0.68 | ALDH1A1 (0.43) | KDM4EALDH1A1KDM2BHSD11B1KMT2A | |
| SCHEMBL8953753 | 0.65 | L3MBTL1 (0.44) | KDM4EALDH1A1KDM2BHSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354865-A | Enzyme inhibitor and inhibiting the leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994005281-A1 | PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1994-03-17 | — | — | WO | disclosed |