Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9307254 | 0.84 | ALOX5 (0.64) | ALOX5ALDH1A1KDM2B | |
| SCHEMBL25890274 | 0.83 | ALOX5 (0.51) | ALOX5ALDH1A1F2 | |
| SCHEMBL4638462 | 0.80 | F2 (0.68) | MRGPRX4F2NR4A2MAOB | |
| SCHEMBL29078315 | 0.79 | CES2 (0.50) | ALDH1A1KDM2B | |
| SCHEMBL8953864 | 0.79 | MAOB (0.47) | ALDH1A1NR4A2KDM2BMAOB | |
| SCHEMBL22717033 | 0.79 | NR4A2 (0.70) | MRGPRX4ALDH1A1NR4A2NAAAKDM2B | |
| SCHEMBL8953796 | 0.78 | KMT2A (0.51) | ALDH1A1NR4A2KDM2BMAOB | |
| SCHEMBL9308116 | 0.78 | KMT2A (0.38) | ALDH1A1KDM2B | |
| SCHEMBL8953863 | 0.78 | ALDH1A1 (0.45) | ALDH1A1NR4A2KDM2BMAOB | |
| SCHEMBL9186121 | 0.77 | MAOB (0.74) | MRGPRX4F2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354865-A | Enzyme inhibitor and inhibiting the leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994005281-A1 | PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1994-03-17 | — | — | WO | disclosed |