Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | GLA | P06280 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056350 | 0.86 | LMNA (0.59) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL15828752 | 0.84 | KDM4E (0.62) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL13267221 | 0.83 | KDM4E (0.54) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL278605 | 0.78 | KIF11 (0.81) | KDM4EALDH1A1CYP1A2KIF11DAO | |
| SCHEMBL29864765 | 0.78 | KIF11 (0.81) | KDM4EALDH1A1CYP1A2KIF11DAO | |
| SCHEMBL19032120 | 0.77 | LMNA (0.60) | KDM4EGAAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2795205 | 0.77 | KDM4E (0.67) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL13560650 | 0.76 | KIF11 (0.61) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL7028425 | 0.75 | KIF11 (0.54) | KDM4EGAAALDH1A1HPGDTP53 | |
| SCHEMBL22501754 | 0.75 | AR (0.69) | KDM4EGLAGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371226-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-12-06 | — | — | US | disclosed |
| CN-1077192-A | The 2-oxoquinoline derivatives | MERCK PATENT GMBH (DE) | 1993-10-13 | — | — | CN | disclosed |
| EP-0561252-A1 | 2-Oxoquinoline derivatives as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | disclosed |