Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.53 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27418510 | 0.97 | LPL (0.53) | LPLLIPGCA2KCNH2LMNA | |
| Lithium Ion SCHEMBL28956379 | 0.97 | LPL (0.53) | LPLLIPGCA2KCNH2LMNA | |
| SCHEMBL31423383 | 0.97 | LPL (0.53) | LPLLIPGCA2KCNH2LMNA | |
| SCHEMBL8672200 | 0.97 | LPL (0.53) | LPLLIPGCA2KCNH2LMNA | |
| Potassium Ion SCHEMBL11713056 | 0.97 | LPL (0.53) | LPLLIPGCA2KCNH2LMNA | |
| SCHEMBL25183200 | 0.97 | LPL (0.53) | LPLLIPGCA2KCNH2LMNA | |
| SCHEMBL30946630 | 0.97 | LPL (0.53) | LPLLIPGCA2KCNH2LMNA | |
| SCHEMBL28463511 | 0.90 | CA2 (0.49) | LPLLIPGCA2KCNH2LMNA | |
| SCHEMBL28417025 | 0.86 | CA2 (0.54) | CA2KCNH2LMNACYP2D6CYP2C9 | |
| SCHEMBL11828390 | 0.85 | LPL (0.57) | LPLLIPGCA2TSHRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5300481-A | Applying serotonin, malatonin and derivatives with surfactant | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-04-05 | — | — | US | disclosed |