SCHEMBL9308593

SCHEMBL9308593

O=C(O)c1ccc2ncccc2c1C(=O)OC(=O)c1c(C(=O)O)ccc2ncccc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
KDM6B O15054 1/20 0.46
KDM6A O15550 1/20 0.46
TET3 O43151 1/20 0.46
KDM4A O75164 1/20 0.46
KDM4B O94953 1/20 0.46
KDM5C P41229 1/20 0.46
KDM4D Q6B0I6 1/20 0.46
TET2 Q6N021 1/20 0.46
ALKBH5 Q6P6C2 1/20 0.46
TET1 Q8NFU7 1/20 0.46
FTO Q9C0B1 1/20 0.46
EGLN1 Q9GZT9 1/20 0.46
KDM4C Q9H3R0 1/20 0.46
KDM2A Q9Y2K7 1/20 0.46
KDM3A Q9Y4C1 1/20 0.46
MAPT P10636 3/20 0.46
IL1B P01584 1/20 0.44
TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9047952 0.93 KDM4E (0.46) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL69562 0.87 KDM4E (0.52) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL29415433 0.87 KDM4E (0.52) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL2127197 0.78 KDM4E (0.59) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL68903 0.78 KDM4E (0.56) KDM4EL3MBTL1MAPTTDP1LMNA
SCHEMBL1759011 0.77 KDM4E (0.56) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL23660919 0.76 IL1B (0.53) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL20424060 0.76 LMNA (0.53) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL28372666 0.76 NAPRT (0.53) KDM4EL3MBTL1KDM6BKDM6ATET3
SCHEMBL6785922 0.76 MAPT (0.58) KDM4EL3MBTL1KDM6BKDM6ATET3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5283335-A Controlling (mono or di)cotyledenous plants AMERICAN CYANAMID COMPANY (US) 1994-02-01 US disclosed