Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.56 |
| ▸ | BACE1 | P56817 | 11/20 | 0.56 |
| ▸ | BCHE | P06276 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.46 |
| ▸ | FABP6 | P51161 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26348201 | 0.78 | HRH4 (0.55) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL13768899 | 0.76 | KMT2A (0.59) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL7841536 | 0.75 | ACHE (0.66) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL22815725 | 0.75 | ACHE (0.70) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL26348162 | 0.75 | MEN1 (0.58) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL7146756 | 0.75 | VEGFA (0.63) | LMNAHTTCYP1A2BPTF | |
| SCHEMBL2002846 | 0.74 | LMNA (0.68) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8355347 | 0.72 | ACHE (0.57) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL14367985 | 0.72 | ACHE (1.00) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL26348587 | 0.72 | ACHE (0.56) | ACHEBACE1BCHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |