Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29227279 | 0.89 | HSD17B10 (0.47) | HSD17B10LMNAGAAELANEMEN1 | |
| SCHEMBL8848542 | 0.81 | ELANE (0.51) | ELANE | |
| SCHEMBL17303478 | 0.79 | LMNA (0.37) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL27778336 | 0.78 | MAPT (0.35) | LMNAELANEKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2028396 | 0.78 | ADH5 (0.32) | ALPL | |
| SCHEMBL2819906 | 0.77 | KDM4E (0.50) | GAAMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL28619404 | 0.76 | NSD2 (0.48) | MEN1KMT2ATDP1MAPTSMN1; SMN2 | |
| SCHEMBL6502581 | 0.76 | LTA4H (0.49) | TSHRDHODHCHEK2 | |
| SCHEMBL28489775 | 0.76 | KDM4E (0.49) | GAAMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL13411813 | 0.75 | ADH5 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374643-A | Aryl urea (thiourea) and cyanoguanidine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1994-12-20 | — | — | US | disclosed |