SCHEMBL2819906

SCHEMBL2819906

O=C(O)c1ccc(-c2nnn[nH]2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.50
ALDH1A1 P00352 4/20 0.50
TP53 P04637 1/20 0.44
TSHR P16473 1/20 0.44
HPGD P15428 3/20 0.44
KMT2A Q03164 3/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
MAP2K4 P45985 1/20 0.42
BCL2L1 Q07817 1/20 0.42
BAD Q92934 1/20 0.42
TTR P02766 1/20 0.42
CSNK2A2 P19784 1/20 0.41
CSNK2B P67870 1/20 0.41
CSNK2A1 P68400 1/20 0.41
GLA P06280 2/20 0.41
GAA P10253 2/20 0.41
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP8 P22894 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28489775 0.98 KDM4E (0.49) KDM4EALDH1A1TP53TSHRHPGD
SCHEMBL2513525 0.90 EGFR (0.47) KDM4EALDH1A1TP53TSHRNPC1
SCHEMBL17303478 0.87 LMNA (0.37) KDM4EALDH1A1HPGDKMT2ANPC1
SCHEMBL2516837 0.86 DHODH (0.46) KDM4EALDH1A1MKNK1MKNK2
SCHEMBL28781255 0.85 MKNK1 (0.49) MKNK1MKNK2
SCHEMBL5485083 0.84 NPC1 (0.44) KDM4EALDH1A1HPGDKMT2ANPC1
SCHEMBL7432657 0.84 XDH (0.51) TP53HPGDKMT2ANPC1RAB9A
SCHEMBL751010 0.84 MKNK1 (0.42) ALDH1A1KMT2AMAP2K4MKNK1MKNK2
SCHEMBL9067093 0.84 KDM4E (0.34) KDM4EALDH1A1HPGDKMT2A
SCHEMBL24690305 0.83 RXRA (0.44) KDM4EALDH1A1BCL2L1BADCSNK2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP claimed
CN-119926404-A Carbonized Co-MOF powder, supported membrane, sandwich structure limited-domain catalytic membrane and preparation method 清华大学深圳国际研究生院 2025-05-06 CN claimed
CN-117757094-A Preparation method and application of EuTb mixed coordination fluorescent rare earth metal-organic framework material 东华理工大学 2024-03-26 CN claimed
US-20240011009-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2024-01-11 US claimed
CN-117106189-A Metal organic framework artificial hydrolase and preparation method and application thereof 华南理工大学 2023-11-24 CN claimed
US-20230220589-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2023-07-13 US claimed
EP-4127157-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-02-08 EP claimed
CN-114805233-A Phenyl tetrazole type XOR inhibitor and preparation method and application thereof 华南理工大学 2022-07-29 CN claimed
WO-2022072560-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2022-04-07 WO claimed
CN-111234243-B Metal organic framework material, preparation method thereof and immunosensor 郑州轻工业大学 2021-10-01 CN claimed
US-20140206825-A1 SUPPORTED ALKOXYLATED ORGANOTIN REACTANT, PREPARATION AND USE FOR HETEROGENEOUS-PHASE SYNTHESIS OF TETRAZOLES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2014-07-24 US claimed
US-20100292334-A1 N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS NEUROSEARCH A/S (DK) 2010-11-18 US claimed
EP-2222308-A1 N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS NeuroSearch AS (DK) 2010-09-01 EP claimed
WO-2009065850-A1 N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS NEUROSEARCH A/S (DK) 2009-05-28 WO claimed
US-6576414-B1 PKsp of said first organic silver salt is at least 0.5 lower than the pKsp of said second silver salt; high speed, storage stable EASTMAN KODAK COMPANY 2003-06-10 US claimed
US-6548236-B1 The dye-providing couplers in the multilayers being different in hue, forming at least three dye images of different visible or non-visible colors EASTMAN KODAK COMPANY 2003-04-15 US claimed
EP-1299769-A1 MIXTURES OF ORGANIC SILVER SALTS IN COLOR PHOTOTHERMOGRAPHIC SYSTEMS EASTMAN KODAK COMPANY (US) 2003-04-09 EP claimed
US-6426181-B2 THE SECOND SILVER SALT IS A THERMAL FOG INHIBITOR THAT PREVENTS DESORPTION OF SENSITIZING DYES FROM THE IMAGING SILVER HALIDE GRAINS AND IS PREFERABLY A MERCAPTO-HETEROCYCLIC COMPOUND EASTMAN KODAK COMPANY 2002-07-30 US claimed
US-20020015928-A1 Mixtures of organic silver salts in color photothermographic systems IRVING LYN M (US) 2002-02-07 US claimed
WO-2001096949-A1 MIXTURES OF ORGANIC SILVER SALTS IN COLOR PHOTOTHERMOGRAPHIC SYSTEMS EASTMAN KODAK COMPANY (US) 2001-12-20 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100292334-A1 N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS CHRNA3, CHRNA6, CHRNA2 KDM4E 2391/4885ALDH1A1 614/4885TP53 4823/4885
US-20140206825-A1 SUPPORTED ALKOXYLATED ORGANOTIN REACTANT, PREPARATION AND USE FOR HETEROGENEOUS-PHASE SYNTHESIS OF TETRAZOLES ALK, TST, TEKT1 KDM4E 3246/4885ALDH1A1 861/4885TP53 2402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.